解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with PC12 cells...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx032
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to determine the outcomes and adverse events for 300 men with prostate cancer treated with 125iodine (125I) brachytherapy with and without external-beam radiation therapy (EBRT) at a single institution in Japan. Between February 2005 and November 2011, 300 consecutive patients with clinically...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx051
更新日期:2017-11-01 00:00:00
abstract::Whole brain irradiation (WBI) has become an indispensible tool in the treatment of head and neck cancer, and it has greatly improved patient survival rate and total survival time. In addition, prophylactic cranial irradiation (PCI) has dramatically decreased the incidence of brain metastatic carcinoma. However, WBI ma...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx041
更新日期:2017-11-01 00:00:00
abstract::The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx030
更新日期:2017-11-01 00:00:00
abstract::Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 f...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx048
更新日期:2017-11-01 00:00:00
abstract::Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen-associated molecular patterns and are indispensable for antibacterial and antiviral immunity. Our previous report showed that ionizing radiation increases the cell surface expressions of TLR2 and TLR4 and enhances their responses to a...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx011
更新日期:2017-09-01 00:00:00
abstract::This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx017
更新日期:2017-09-01 00:00:00
abstract::The aim of this study was to compare the anti-oxidative and anti-inflammatory activities of gamma-irradiated persimmon leaf extract (GPLE) with those of non-irradiated persimmon leaf extract (PLE). Ethanolic extract of persimmon leaf was exposed to gamma irradiation at a dose of 10 kGy. After gamma irradiation, the co...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx013
更新日期:2017-09-01 00:00:00
abstract::Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) for 3D image-guided brachytherapy (3D-IGBT) for cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrw109
更新日期:2017-05-01 00:00:00
abstract::Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw110
更新日期:2017-05-01 00:00:00
abstract::The aim of the study was to compare clinical outcomes and toxicity between 3D conformal radiotherapy (3DCRT) and image-guided intensity-modulated radiotherapy (IG-IMRT) administered through helical tomotherapy in locally advanced rectal cancer (LARC) patients receiving preoperative chemoradiotherapy. We reviewed 144 p...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw098
更新日期:2017-03-01 00:00:00
abstract::Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave the fluence at the...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw106
更新日期:2017-03-01 00:00:00
abstract::Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw086
更新日期:2017-01-01 00:00:00
abstract::In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially th...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw083
更新日期:2017-01-01 00:00:00
abstract::The brachytherapy dose calculations used in treatment planning systems (TPSs) have conventionally been performed assuming homogeneous water. Using measurements and a Monte Carlo simulation, we evaluated the dosimetric impact of an air passage on brachytherapy for bronchus cancer. To obtain the geometrical characterist...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw072
更新日期:2016-11-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common progressive and irreversible neurodegenerative disease and it is caused by neuronal death in the brain. Recent studies have shown that non-ionizing radiofrequency (RF) radiation has some beneficial cognitive effects in animal models of AD. In this study, we examined the effe...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw040
更新日期:2016-11-01 00:00:00
abstract::This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiat...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw043
更新日期:2016-11-01 00:00:00
abstract::The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw052
更新日期:2016-09-01 00:00:00
abstract::The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw075
更新日期:2016-09-01 00:00:00
abstract::This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw053
更新日期:2016-09-01 00:00:00
abstract::PU-H71, a heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still room for improvement, particularly in terms of tumor-specific radiosensitizat...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw054
更新日期:2016-09-01 00:00:00
abstract::In hypofractionated stereotactic radiotherapy (SRT), high doses per fraction are usually used and the dose delivery pattern is different from that of conventional radiation. The daily dose is usually given intermittently over a longer time compared with conventional radiotherapy. During prolonged radiation delivery, s...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw015
更新日期:2016-08-01 00:00:00
abstract::The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw024
更新日期:2016-07-01 00:00:00
abstract::Preliminary results of the Polish epidemiology study on eye lens opacities among interventional cardiologists (ICs), based on the methodology proposed by ELDO (epidemiological studies of radio-induced cataracts in interventional cardiologists and radiologists: methodology implementation), are presented. The aim of the...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw019
更新日期:2016-07-01 00:00:00
abstract::Irregular breathing can influence the outcome of 4D computed tomography imaging and cause artifacts. Visual biofeedback systems associated with a patient-specific guiding waveform are known to reduce respiratory irregularities. In Japan, abdomen and chest motion self-control devices (Abches) (representing simpler visu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv106
更新日期:2016-07-01 00:00:00
abstract::Due to the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, the evacuees from Namie Town still cannot reside in the town, and some continue to live in temporary housing units. In this study, the radon activity concentrations were measured at temporary housing facilities, apartments and detached houses in Fukush...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv102
更新日期:2016-07-01 00:00:00
abstract::XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv086
更新日期:2016-03-01 00:00:00
abstract::The aim of this study was to describe our initial experience with a gold flexible linear fiducial marker and to evaluate the safety and technical and clinical efficacy of stereotactic body radiotherapy using this marker for malignant liver tumors. Between July 2012 and February 2015, 18 patients underwent percutaneous...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv099
更新日期:2016-03-01 00:00:00
abstract::We investigated the efficacy and safety of albumin-bound paclitaxel (nab-PTX) and carboplatin (CBDCA) with concurrent radiotherapy for unresectable locally advanced non-small-cell lung cancer (NSCLC). Patients with Stage III NSCLC and an Eastern Cooperative Oncology Group performance status of 0 or 1 were eligible. Co...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv062
更新日期:2016-01-01 00:00:00
abstract::To clarify the nature of the genes that contribute to the radiosensitivity of human hematopoietic stem/progenitor cells (HSPCs), we analyzed the gene expression profiles detected in HSPCs irradiated with 2 Gy X-rays after culture with or without an optimal combination of hematopoietic cytokines. Highly purified CD34(+...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv071
更新日期:2016-01-01 00:00:00
abstract::We aimed to investigate the effect of chronic radiation exposure associated with the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on the testes of boar and inobuta (a hybrid of Sus scrofa and Sus scrofa domestica). This study examined the contamination levels of radioactive caesium (Cs), especially (134)Cs an...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv070
更新日期:2015-12-01 00:00:00
abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv047
更新日期:2015-11-01 00:00:00
abstract::We generated low-flux X-ray micro-planar beams (MPBs) using a laboratory-scale industrial X-ray generator (60 kV/20 mA) with custom-made collimators with three different peak/pitch widths (50/200 μm, 100/400 μm, 50/400 μm). To evaluate normal skin reactions, the thighs of C3H/HeN mice were exposed to 100 and 200 Gy MP...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv037
更新日期:2015-09-01 00:00:00
abstract::The purpose of this study was to analyze the patterns of care and outcomes of patients with FIGO Stage I/II cervical cancer who underwent definitive radiotherapy (RT) at multiple Japanese institutions. The Japanese Radiation Oncology Study Group (JROSG) performed a questionnaire-based survey of their cervical cancer p...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrv036
更新日期:2015-09-01 00:00:00
abstract::Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony format...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv039
更新日期:2015-09-01 00:00:00
abstract::Single-photon emission computed tomography/computed tomography (SPECT/CT) demonstrates the precise location of the sentinel lymph nodes (SLNs) in patients with breast cancer. We evaluated the relationship between SLNs and postoperative tangential fields by using SPECT/CT images. Subjects included 72 patients with earl...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv035
更新日期:2015-09-01 00:00:00
abstract::The aim of this study was to evaluate the effectiveness and tolerability of definitive chemo-radiation or radiotherapy alone in patients with esophageal cancer. We retrospectively analyzed the medical records of n = 238 patients with squamous cell carcinoma or adenocarcinoma of the esophagus treated with definitive ra...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv022
更新日期:2015-07-01 00:00:00
abstract::Herein we summarize the public health actions taken to mitigate exposure of the public to radiation after the Fukushima accident that occurred on 11 March 2011 in order to record valuable lessons learned for disaster preparedness. Evacuations from the radiation-affected areas and control of the distribution of various...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrv013
更新日期:2015-05-01 00:00:00
abstract::Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru122
更新日期:2015-05-01 00:00:00
abstract::Photon irradiation has been repeatedly suspected of increasing tumor cell motility and promoting locoregional recurrence of disease. This study was set up to analyse possible mechanisms underlying the potentially radiation-altered motility in medulloblastoma cells. Medulloblastoma cell lines D425 and Med8A were analyz...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru120
更新日期:2015-05-01 00:00:00